Evodiamine synergizes with doxorubicin in the treatment of chemoresistant human breast cancer without inhibiting P-glycoprotein.

Drug resistance is one of the main hurdles for the successful treatment of Flavorings breast cancer.The synchronous targeting of apoptosis resistance and survival signal transduction pathways may be a promising approach to overcome drug resistance.In this study, we determined that evodiamine (EVO), a major constituent of the Chinese herbal medicine

read more



Abundance and Compositions of B-Vitamin-Producing Microbes in the Mammalian Gut Vary Based on Feeding Strategies

ABSTRACT Mammals maintain close associations with gut microbes that provide numerous nutritional benefits, including vitamin synthesis.While most mammals obtain sufficient vitamins from their diets, deficiencies in various B vitamins (biotin, cobalamin, riboflavin, thiamine, etc.) are reported in captive animals.Biomedical and agricultural research

read more

From leaf to whole-plant water use efficiency (WUE) in complex canopies: Limitations of leaf WUE as a selection target

Plant water use efficiency (WUE) is becoming a key issue in semiarid areas, where crop production relies on the use of large volumes of water.Improving WUE is necessary for securing environmental sustainability of food production in these areas.Given that climate change predictions include increases in temperature and drought in semiarid regions, i

read more